Vista Murrieta High School (VMHS) is a comprehensive, four-year high school located in Murrieta, California, United States. It is operated by the Murrieta Valley Unified School District. It opened in August 2003, relieving the overcrowding at Murrieta Valley High School, which had been the district’s only comprehensive high school until that time. During the 2022–2023 school year, the school served over 3,800 students. The campus sits on 68 acres (280,000 m²)^[3] overlooking most of the City of Murrieta to the south.

VMHS is a four-year comprehensive high school accredited by the Western Association of Schools and Colleges (as of 2006).

The current principal is Celeste Scallion, who took over after the 2020–2021 school year, after former principal Mick Wager.

This school was named “the most spirited school in the nation” from MaxPreps.com on March 31, 2009, as well as 2010.^[4] It was awarded the same title from Varsity.com for the 2015–2016 school year,^[5] and is currently a finalist for the title in the 2022–2023 school year. It is now a California Distinguished School.

In the 2022–2023 school year, Vista Murrieta celebrated its 20th anniversary, after opening in 2003. Celebrations included a 20th anniversary themed Homecoming, 20th anniversary flags on light posts around the school, and merchandise including sweatshirts and baseball caps. Although this was their 20th year open, the school’s 20th graduating class will walk in 2026.